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Eleven (58%) reported results on the primary outcome. The majority of the studies were conducted in the US (74%, n = 14) 68% (n = 13) of the studies were experimental, the rest having an observational study design. Nineteen studies were included in the systematic review.

Considered secondary outcomes included willingness to receive immunization, attitudes and perceptions toward vaccination, and perceived helpfulness of the intervention. The primary outcome was a measure of vaccination (vaccine uptake or vaccine coverage). We limited the study setting to countries that are members of the Organisation for Economic Co-operation and Development (OECD). We focused on interventions that targeted recommended vaccinations for children, adolescents and adults and: (1) aimed at increasing community demand for immunizations, or (2) were provider-based interventions. Studies published from January 1999 to September 2013 were identified by searching electronic resources (Pubmed, Embase), manual searches of references and expert consultation. We conducted a systematic literature review.

To systematically collect and summarize the available evidence on the effectiveness of interventions that apply new media to promote vaccination uptake and increase vaccination coverage. Progress in the field of communication technology might provide useful tools to enhance immunization strategies. However, in many countries coverage rates of routinely recommended vaccines are still below the targets established by international and national advisory committees. In high and middle-income settings, immunization coverage is relatively high. Vaccine-preventable diseases (VPD) are still a major cause of morbidity and mortality worldwide.

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